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Technology & Science

A New Era in Respiratory Testing

From Lab-Based to Handheld

Traditional methods for assessing lung function – such as Body Plethysmography and Nitrogen Washout – have long been the standard in respiratory diagnostics. However, they require large,
complex equipment, dedicated testing rooms, and lengthy procedures that are often uncomfortable for patients and inconvenient for clinics. While clinically effective, these systems are not always
practical for routine or widespread use

Innovative Approach to Pulmonary Diagnostics

STS replaces the need for multiple diagnostic systems with a single, compact, handheld unit.

At the core of this innovation is TechnoPulm’s
patented dynamic process technology,

Traditional lung volume measurements rely on large systems with sealed chambers and controlled environments. Understanding that the thermodynamic principles behind these systems are not suitable for portable use, we developed a completely new measurement approach. Our dynamic process technology combines custom-designed hardware with proprietary algorithms to capture accurate pulmonary data during real-time exhalation.

The technological innovation that enabled miniaturization into a handheld device is based on a novel flow diffuser, designed to achieve a rapid transition from turbulent to laminar flow, allowing highly accurate pressure measurements. This is complemented by a flow monitoring and control mechanism that utilizes an algorithmically guided mechanical shutter to create a unique airflow envelope containing two distinct pressure peaks of the exhaled air.

The unique flow profile, achieved by TechnoPulm’s technology, presents two pressure peaks occurring within the short time window of a forceful exhalation. This profile enables highly accurate measurements, as during this brief moment of exhalation, the pressure differences between the alveoli, lungs, and mouth are minimized, allowing the measured pressure to reliably represent true pulmonary and alveolar pressures.

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Immediate patient condition analysis

The STS device leverages an innovative sensing method combined with an advanced AI algorithm to deliver immediate, on-screen graphical analysis of the patient’s pulmonary condition

Artificial Intelligence (AI)

  • Reliable detection of any pulmonary condition
  • Drug therapy efficiency
  • Converting the forced exhalation results graph that displays the patient's condition and severity

By leveraging the second law of thermodynamics and precisely controlling the airflow during the patient’s exhalation phase, it is possible to manipulate the resulting pressure profile and generate additional pressure peaks. The concept of producing a dual-peak pressure pattern—synchronized with pulmonary respiration and diffusion processes—combined with solving a system of equations that models airflow dynamics, enables comprehensive calculation of the patient’s lung function parameters.

The unique pressure profile of each patient serves as a personalized signature of their lung function at the time of testing. This profile is converted into a numerical signature, which can be further translated into a graphical representation—providing a visual ‘fingerprint’ that reflects the specific characteristics of the patient’s respiratory condition. This graphical signature not only helps differentiate between disease types but also enables pattern recognition. By building a comprehensive database and applying AI-based analysis, it becomes possible to develop predictive tools for tracking disease progression through periodic monitoring

Restrictive Patient

Obstructive Patient

Healthy Patient

For Technical Specifications

Technology Comparison

Lung volume measurement can be performed using various technologies, including body plethysmography, which assesses thoracic gas volume by measuring pressure changes in a sealed chamber, and spirometry, which estimates lung volumes based on airflow during forced breathing maneuvers. Additional methods include gas dilution techniques (like helium or nitrogen washout)

STS
(Dynamic Process)

  • Portable
  • Comfortable & Easy
  • Accessible
  • Affordable
  • Fast
  • Low maintenance
  • Spirometry
  • Volumes
  • Resistance
  • Compliance

Spirometry
(Standalone)

  • Portable
  • Comfortable & Easy
  • Accessible
  • Affordable
  • Fast
  • Low maintenance
  • Spirometry
  • Volumes
  • Resistance
  • Compliance

Body
Plethysmography

  • Portable
  • Comfortable & Easy
  • Accessible
  • Affordable
  • Fast
  • Low maintenance
  • Spirometry
  • Volumes
  • Resistance
  • Compliance

Nitrogen
Washout

  • Portable
  • Comfortable & Easy
  • Accessible
  • Affordable
  • Fast
  • Low maintenance
  • Spirometry
  • Volumes
  • Resistance
  • Compliance

Want to learn more about the science behind STS?

Contact us

Nitrogen Washout is a traditional method used to estimate lung volumes, particularly Functional Residual Capacity (FRC), Residual Volume (RV), and Total Lung Capacity (TLC). It is based on a gas dilution principle, where the amount of nitrogen exhaled is used to calculate the volume of air remaining in the lungs after a normal breath

  • The patient breathes 100% oxygen to flush out nitrogen from the lungs
    Exhaled nitrogen is tracked until levels drop below 2%, and lung volume is calculated based on the total nitrogen exhaled
  • The Nitrogen Washout method takes up to 10 minutes and requires steady breathing and a proper seal
  • The Nitrogen Washout method requires specialized equipment and trained staff and is not ideal for oxygen-dependent patients
Technology Comparison

Body plethysmography is a standard method used to measure static lung volumes, particularly Total Lung Capacity (TLC) and Residual Volume (RV)

  • The patient sits in a sealed, airtight chamber (also called a body box) and breathes through a mouthpiece
  • As the patient breathes against a closed shutter, changes in pressure inside the box and the lungs are measured, applying Boyle’s Law to calculate lung volumes
  • While accurate, the method is time-consuming, uncomfortable, and requires a dedicated lab setup and trained technicians. Some patients—especially the elderly, claustrophobic, or pediatric—may find the enclosed space distressing
Technology Comparison

The patented dynamic process technology behind the STS (Spiro-Test System) introduces a new way to measure lung function by applying the first law of thermodynamics to real-time respiratory flow.

Unlike traditional methods such as body plethysmography, which rely on static gas laws and require enclosed chambers, or nitrogen washout, which uses gas dilution techniques and specialized gases, the STS captures and analyzes the dynamic relationship between airflow, pressure, and energy change during a natural exhalation.

As the patient exhales through a custom-designed flow system, internal sensors measure pressure and airflow under changing resistance. This data is processed by a proprietary algorithm that calculates lung volumes, airway resistance, and lung compliance—accurately and efficiently—without the need for a body box or gas-based systems. The result is a fast, non-invasive, and clinically reliable test that fits in a handheld device, making advanced respiratory diagnostics accessible in any setting

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